Silexion Therapeutics Presented The LODER™ Phase 2 Summary Results In The 2023 ESMO Immuno-Oncology Congress
October 30, 2023
![silexion](/sites/default/files/2023-12/silexion.png)
Results from a multinational Phase 2 clinical study (Protact Trial) of siRNA directed against the oncogenic KRAS G12D and G12V mutations in an extended release formulation (Loder™) was presented at the 2023 European Society for Medical Oncology (ESMO) annual congress (Abstract 1626P). The key endpoint was an overall survival advantage in non-resectable localized pancreatic cancer patients that bear the KRAS G12D/V mutation when treated with the Loder™plus standard of care chemotherapy vs standard of care chemotherapy.
About 90% of pancreatic cancer patients have a mutagenic KRAS mutation and Silexion’s product is directed to about 75% of the KRAS mutations for this cancer population. The life expectancy of these patients treated with standard of care chemotherapy is about 14 months.
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ESMO is the European Society for Medical Oncology. Representing more than 34,000 oncology professionals in 170 countries, ESMO is a reference for oncology education and information.
Founded in 1975, ESMO has European roots with a global reach. Home for all oncology stakeholders, ESMO connects professionals with diverse expertise and experience. Its education and information resources support an integrated multi-professional approach to cancer care, from a medical oncology perspective.
ESMO seeks to erase boundaries in cancer care, whether between countries or specialities, and pursue its mission across oncology, worldwide.